Computational Protein Engineer

Job Description

My client seeks a **Computational** **Protein Engineer**to build and lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.

**The ideal candidate will take on the following responsibilities:**

* Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
* Drive protein expression, purification, and characterization workflows across multiple formats
* Design and execute binding and functional assays to evaluate and iterate on engineered proteins
* Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
* Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies

**The ideal candidate will possess the following qualifications:**

* PhD in biochemistry, molecular biology, protein biochemistry, or related discipline
* Hands-on expertise in protein expression, purification, and characterization
* Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
* Peer-reviewed publications and/or patents in antibody or protein engineering
* Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
* Proven ability to lead technical teams and manage complex, multi-faceted projects
* Outstanding written and verbal communication skills

**This role is onsite in Rockville, MD.**